Elevated crp levels are seen in infection, in autoimmune disease, in surgery, meconium aspiration and recent vaccination. Prompt diagnosis and treatment of neonatal earlyonset sepsis are crucial to prevent severe morbidity and mortality. Crp is a good marker for diagnosis of neonatal sepsis. Accuracy of serum procalcitonin for the diagnosis of. Reference values for pct in sepsis patients the absolute level of pct concentrations increase with increasing severity of disease.
Procalcitonin, were measured at the moment of clinical diagnosis and after 24. Research article open access procalcitonin versus c. Serum procalcitonin pct has been proposed as an early marker of infections in neonates. However, as an expression of individually different immune responses and different clinical situations, the same focus of infection may be associated with varying individual elevations in pct concentrations. This study investigated the value of pct in the diagnosis of neonatal sepsis. But some investigators questioned the diagnostic accuracy of pct in detecting of. Neonatal sepsis is a common cause of morbidity and mortality in newborn infants. Procalcitonina, sepsis, recien nacidos, biomarcadores.
Uti is discovered as part of an evaluation for neonatal sepsis 1. Pdf procalcitonin in detecting neonatal nosocomial sepsis. Procalcitonin pct was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. In a recent study koksal et al concluded that serum procalcitonin level was superior to serum crp level in terms of early diagnosis of neonatal sepsis, in detecting the severity of the illness and in evaluation of the response to. Volume 18, issue 3, julyseptember 2014, pages 8692. Research article open access procalcitonin versus creactive. Pdf diagnostic value of procalcitonin in neonatal sepsis. To investigate the accuracy of procalcitonin pct as a diagnostic marker of nosocomial sepsis ns and define the most accurate cutoff to distinguish infected from uninfected neonates. Also, the crp values do not rise significantly until almost 1448 hr after the onset of infection 57. Neonatal sepsis is a clinical syndrome of systemic illness accompanied by bacteremia occurring in the first month of life. Accuracy of serum procalcitonin for the diagnosis of sepsis. The overall incidence of primary sepsis is 15 live births.